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    劉潤輝
    發布人: 網站管理員 發布時間: 2019-12-09 作者: 訪問次數: 111118


    劉潤輝    教授、博導

    華東理工大學特聘教授

    研究方向:高分子生物材料

    Emailrliu@ecust.edu.cn       Tel: 021-64253402

    辦公室:徐匯校區科輔二樓二層C203   

    郵政地址:上海市梅隴路130546信箱

    招生專業:材料科學與工程

    本課題組招收博士、碩士研究生和博士后

    課題組開展交叉領域研究,歡迎對以下某個方向有興趣的同學加入我們課題組: 有機合成、高分子合成、生物、微生物。

    .........................................................................................................................................................................................................................................................................

    教育及研究經歷:

    2004-2009 美國 普渡大學(Purdue University) 博士

    2009-2010 美國 加州理工學院(California Institute of Technology) 博士后

    2010-2014 美國 威斯康星大學麥迪遜校區(University of Wisconsin-Madison) 博士后

    .........................................................................................................................................................................................................................................................................

    主要研究方向:

    模擬天然蛋白功能的合成高分子生物材料,包括:
     1.
    功能化聚合物單體的合成;多功能高分子材料的制備及合成方法研究
     2.
    生物相容、生物可降解高分子材料的研究與開發
     3.
    抗細菌、抗真菌生物材料的研制與作用機理研究
     4.
    具有細胞黏附bob电竞竞猜、細胞選擇功能的生物材料研究及在組織修復中的應用
     5.
    抗非特異性蛋白吸附及微生物生物膜形成的防污材料研究及在生物醫學工程領域的應用
     6.
    蛋白類及小分子藥物的體內傳輸和可控釋放研究

    .........................................................................................................................................................................................................................................................................

    代表性學術論文:

    1.Chen, Q.; Yu, S.; Zhang, D.; Zhang, W.; Zhang, H.; Zou, J.; Mao, Z.; Yuan, Y.; Gao C.; Liu, R.*, Impact of Antifouling PEG Layer on the Performance of Functional Peptides in Regulating Cell Behaviors.  J. Am. Chem. Soc. 2019, 141, 16772

    (Selected as the JACS supplementary cover paper)

    (Highlighted by Sci. China Chem, 2019, DOI: 10.1007/s11426-019-9654-9)

    (Highlighted by CCL, 2019, DOI: 10.1016/j.cclet.2019.10.038)


    2.Wu, Y.; Zhang, D.; Ma, P.; Zhou, R.; Hua, L.; Liu, R.*, Lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N-carboxyanhydrides. Nat. Commun. 2018, 9 (1), 5297.

    (Selected as the editor’s choice)

    (Spotlight by Acta Polymerica Sinica, 2019, 50(2): 99)

    (Spotlight by J. Functional Polymers, 2019, 32(2): 120)

    (Spotlight reviewed by Materials Reports, 2019, 33(1): 1)


    3.Ding, X.; Duan, S.; Ding, X.; Liu, R.*; Xu, F.*, Versatile Antibacterial Materials: An Emerging Arsenal for Combatting Bacterial Pathogens. Adv. Funct. Mater. 2018, 28 (40), 19.


    4.Qi. F; Qian, Y.; Shao, N.; Zhou, R.; Zhang, S.; Lu Z.; Zhou, M.; Xie, J.; Wei, T.; Yu, Q.;, Liu, R., Practical Preparation of Infection-Resistant Biomedical Surfaces from Antimicrobial β-Peptide Polymers. ACS Appl. Mater. Interfaces 2019, 11 (21), 18907-18913.


    5.Qian, Y.; Qi, F.; Chen, Q.; Zhang, Q.; Qiao, Z.; Zhang, S.; Wei, T.; Yu, Q.; Yu, S.; Mao, Z.; Gao, C.; Ding, Y.; Cheng, Y.; Jin, C.; Xie, H.; Liu, R.*, Surface Modified with a Host Defense Peptide-Mimicking beta-Peptide Polymer Kills Bacteria on Contact with High Efficacy. ACS Appl. Mater. Interfaces 2018, 10 (18), 15395-15400.


    6.Liu, R.; Chen, X.; Falk, S.; Masters, K. S.; Weisblum, B.; Gellman, S. H. “Nylon-3 Polymers Active against Drug-Resistant Candida albicans Biofilms” J. Am. Chem. Soc. 2015, 137: 2183-2196.


    7.Liu, R.; Chen, X.; Falk, S.; Mowery, B.; Karlsson, A.; Weisblum, B.; Palecek, S.; Masters, K. S.; Gellman, S. H. “Structure–Activity Relationships among Antifungal Nylon-3 Polymers:  Identification of Materials Active Against Drug-Resistant Strains of Candida albicans”, J. Am. Chem. Soc. 2014, 136: 4333-4342.

    (Highlighted by SciBX, SciBX 7(11), 2014, 315)


    8.Liu, R.; Chen, X.; Chakraborty, S.; Lemke, J.; Hayouka, Z.; Chow, C.; Welch, R.; Weisblum, B.; Masters, K. S.; Gellman, S. H. “Tuning the Biological Activity Profile of Antibacterial Polymers via Subunit Substitution Pattern”, J. Am. Chem. Soc. 2014, 136: 4410-4418.

    (Highlighted by SciBX: SciBX 7(15), 2014, 441)


    9.Liu, R.#; Suárez, J. M.#; Weisblum, B.; Gellman, S. H.; and McBride, S. M. “Polymers Active Against Clostridium difficile Vegetative Cell Growth and Spore Outgrowth.” J. Am. Chem. Soc. 2014, 136, 14498-14504. (equal contribution)

    (Highlighted by SciBX: SciBX 7(43), 2014, 1263)


    10.Chakraborty, S.#; Liu, R.#; Hayouka, Z.; Chen, X.; Ehrhardt, J.; Lu, Q.; Burke, E.; Yang, Y.; Weisblum, B.; Wong, G. C. L.; Masters, K. S; and Gellman, S. H. “Ternary nylon-3 copolymers as host-defense peptide mimics: beyond hydrophobic and cationic subunits.” J. Am. Chem. Soc. 2014, 136, 14530-14535. (equal contribution)


    11.Liu, R.; Chen, X.; Gellman, S. H.; Masters, K. S. “Nylon-3 Polymers that Enable Selective Culture of Endothelial Cells”,  J. Am. Chem. Soc. 2013, 135: 16296-16299.


    12.Liu, R.; Chen, X.; Hayouka, Z.; Chakraborty, S.; Falk, S. P.; Weisblum, B.; Masters, K. S.; Gellman, S. H. “Nylon-3 Polymers with Selective Antifungal Activity.” J Am Chem Soc. 2013, 135, 5270-5273.

    (Featured in JACS Spotlights, J. Am. Chem. Soc. 2013, 135: 5933?5933)


    13.Hayouka, Z.; Chakraborty, S.; Liu, R.; Boersma, M. D.; Weisblum, B.; Gellman, S. H. “Interplay among Subunit Identity, Subunit Proportion, Chain Length, and Stereochemistry in the Activity Profile of Sequence-Random Peptide Mixtures.” J. Am. Chem. Soc. 2013, 135: 11748-11751.


    14.Liu, R.; Chanthamontri, C.; Han, H.; Hernández-Torres, J.M.; Wood, K.V.; Mcluckey, S.A.; Wei, A. “Solid-Phase Synthesis of α-Glucosamine Sulfoforms with Fragmentation Analysis by Tandem Mass Spectrometry.” J. Org. Chem. 2008, 73: 6059-6072.  



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